Birgit Dreier

Pre-assembly of biomolecular condensate seeds drives RSV replication

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma

This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.

Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage {varphi}2638A

This study investigates the role of SV isoforms of the staphylococcal phage φ2638A endolysin during infection, showing they form heterodimers with the full-length endolysin to enhance lytic activity.

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

This study develops DARPin-based tools to study gephyrin and inhibitory synapses, revealing new interactors and binding modes.