Author

Peer R. E. Mittl

University of ZurichORCID 0000-0002-3348-3147Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andreas PlückthuniD· 2 shared Andri Häfliger· 1 shared Anja P. KelleriD· 1 shared Anna M. Sobieraj· 1 shared Birgit DreieriD· 1 shared Cedric Iseli· 1 shared Dorothea WinkelvoßiD· 1 shared Jonas N. Maskos· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Andreas PlückthunORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Steric shielding of the KRAS4B hypervariable region enables isoform-specific inhibition of prenylation

Jonas N. Maskos, Yvonne Stark, Valentin Rohner, Andri Häfliger, Dorothea Winkelvoß, Kari Kopra, Peer R. E. Mittl, Andreas Plückthun

This paper develops a dArmRP that selectively shields the KRAS4B hypervariable region, blocking prenylation and reducing membrane localization without affecting other KRAS isoforms.

bioRxiv · Mar 20, 2026 · PreprintBiochemistry

Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage {varphi}2638A

Léa V. Zinsli, Anna M. Sobieraj, Patrick J. Ernst, Susanne Meile, Samuel Kilcher, Cedric Iseli, Anja P. Keller, Birgit Dreier, Peer R. E. Mittl, Andreas Plückthun, Martin J. Loessner, Mathias Schmelcher, Matthew Dunne

This study investigates the role of SV isoforms of the staphylococcal phage φ2638A endolysin during infection, showing they form heterodimers with the full-length endolysin to enhance lytic activity.

bioRxiv · Jan 16, 2024 · PreprintMolecular Biology