Author

Patrick J. Ernst

University of MinnesotaORCID 0000-0001-6037-1856Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Andreas PlückthuniD· 1 shared Anja P. KelleriD· 1 shared Anna M. Sobieraj· 1 shared Bhairab N. SinghiD· 1 shared Birgit DreieriD· 1 shared Brenda M. OgleiD· 1 shared Cedric Iseli· 1 shared Forum D. KamdariD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Andreas PlückthunORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 8, 2024

HCM-associated mutations in MYH6/7 drive pathologic expression of TGF-β1 in cardiomyocytes within weeks of developmental specification

Jeanne Hsieh, Megan A. L. Hall, Mohammad Shameem…·Brenda M. Ogle

This study shows that HCM-associated mutations in MYH6/7 lead to increased TGF-β1 expression in cardiomyocytes, driving fibroblast activation and ECM changes within weeks of developmental specification.

DOI 10.1101/2024.08.08.606705

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJan 16, 2024

Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage {varphi}2638A

Léa V. Zinsli, Anna M. Sobieraj, Patrick J. Ernst…·Matthew Dunne

This study investigates the role of SV isoforms of the staphylococcal phage φ2638A endolysin during infection, showing they form heterodimers with the full-length endolysin to enhance lytic activity.

DOI 10.1101/2024.01.16.575832

experimental assay

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