Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar‐Maia, María E. Figueroa, Benjamin David Singer, Aakrosh Ratan, Panagiotis Ntziachristos, Chongzhi Zang
The paper identifies cancer-specific CTCF binding patterns across six cancer types and shows they are linked to oncogenic transcriptional changes without always involving DNA methylation or mutations.
Genome biology · Sep 15, 2020Peer-reviewedGenomics