Kyle P. Eagen

BET BD2 inhibition facilitates SPOP-mediated degradation of chromatin-associated BRD4/BRD4-NUT, a therapeutic vulnerability in NUT carcinoma

The paper shows that selective inhibition of BRD4-BD2 promotes SPOP-mediated degradation of BRD4/BRD4-NUT in NUT carcinoma, leading to better therapeutic outcomes than pan-BET inhibition.

NSD3 stabilizes nuclear compartmentalization and promotes megabase-scale chromatin interactions

The paper identifies NSD3 as a factor that stabilizes nuclear compartmentalization and promotes long-range chromatin interactions in both fusion-positive and fusion-negative cells.

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

The paper identifies cancer-specific CTCF binding patterns across six cancer types and shows they are linked to oncogenic transcriptional changes without always involving DNA methylation or mutations.

Polycomb-Mediated Chromatin Loops Revealed by a Sub-Kilobase Resolution Chromatin Interaction Map

The paper identifies chromatin loops in Drosophila using Hi-C and finds that they are associated with Polycomb group proteins rather than CTCF, and are linked to gene repression.