Emmalee R. Adelman

A ncBAF to cBAF Switch Regulates Human Hematopoietic Progenitor Myeloid Differentiation

This study shows that BRD9 regulates myeloid differentiation in human HSPC by switching ncBAF to cBAF, leading to increased MDSC generation and IL-8 secretion.

The chromatin reader protein MLLT1 is critical to maintain normal B lymphopoiesis

This study shows that MLLT1 is essential for normal B lymphopoiesis, as its deletion in mice leads to reduced B cell development and altered gene expression.

The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis

This study shows the MLLT3 YEATS domain binds both histone marks and the 7SK RNA, influencing hematopoietic lineage commitment and gene expression.

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

The paper identifies cancer-specific CTCF binding patterns across six cancer types and shows they are linked to oncogenic transcriptional changes without always involving DNA methylation or mutations.