Alexandre Gaspar‐Maia

This study shows that diet-induced obesity disrupts circadian β-cell function more in male mice than females, with time-restricted feeding partially restoring these effects.

This study shows that vitamin D signaling activation suppresses platinum-induced ovarian cancer stem cell plasticity, reducing stemness and tumor growth in vivo.

The paper identifies a TIP60 coactivator switch in neuroendocrine prostate cancer, revealing a therapeutic target for MYC-driven diseases.

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

The paper shows glucocorticoid exposure reveals the function of non-coding genetic variants linked to disease risk by influencing gene expression in relevant biological processes.

This study uses single cell multiomic analyses to show DNMT3A mutations in clonal hematopoiesis worsen inflammatory outcomes in COVID-19 by increasing IL32 expression and chromatin accessibility.

The paper identifies cancer-specific CTCF binding patterns across six cancer types and shows they are linked to oncogenic transcriptional changes without always involving DNA methylation or mutations.