Morphogenesis of the muscular ventricular septum of the mouse heart is driven by retinoic acid signalling to myocardium
Tobias Holm Bønnelykke, Celia Coulon, Rachel Sturny, Marie Couderc, Claudio R. Cortés, C. Rousset, Diptarka Saha, Damien Marchese, Christopher De Bono, Lucile Miquerol, Gonzalo del Monte‐Nieto, Stéphane Zaffran, Robert G. Kelly
This study shows that retinoic acid signaling in myocardium drives the formation of the muscular ventricular septum in mouse hearts, with defects leading to congenital heart defects.
bioRxiv · Aug 12, 2026 · PreprintDevelopmental Biology