Stéphane Zaffran

This study shows that retinoic acid signaling in myocardium drives the formation of the muscular ventricular septum in mouse hearts, with defects leading to congenital heart defects.

This study investigates how EGFR regulates wall shear stress-induced signaling in aortic valve cells and identifies its interaction with PIEZO1 in mechanotransduction.

The paper refines a human heart atlas using multi-modal data from the first trimester, identifying novel cell types and spatial features in cardiac development.

This study shows that mouse embryonic stem cell-derived gastruloids can differentiate into both cardiac and skeletal muscle lineages, revealing insights into cardiopharyngeal mesoderm specification.

The paper analyzes clinical and genetic factors in patients with bicuspid aortic valve to identify predictors of valve dysfunction and genetic pathways involved in degeneration.

This study investigates the role of Hoxb1 in regulating cardiac progenitor cell patterning and differentiation, showing its negative regulation of posterior SHF differentiation and its impact on congenital heart defects.

This study shows that PIEZO1 is essential for outflow tract and aortic valve development in zebrafish and identifies PIEZO1 variants linked to bicuspid aortic valve in humans.

This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.

This study shows that ectopic Hoxb1 expression in neural crest cells causes craniofacial and cardiac malformations, highlighting its role in development.