Robert G. Kelly

Morphogenesis of the muscular ventricular septum of the mouse heart is driven by retinoic acid signalling to myocardium

This study shows that retinoic acid signaling in myocardium drives the formation of the muscular ventricular septum in mouse hearts, with defects leading to congenital heart defects.

Transient formation of collaterals contributes to the restoration of the arterial tree during cardiac regeneration in neonatal mice

This study shows that transient collateral arteries form during cardiac regeneration in neonatal mice, aiding in LAD repair and perfusion restoration, while persistent collaterals are seen in non-regenerating hearts.

A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome.

The paper identifies lineage regionalization defects in a mouse model of DiGeorge syndrome using vitamin B12 treatment and shows that SLUG+ cells are mislocalized and partially rescued by treatment.

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm

This study identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm using single-cell RNA-sequencing and shows its role in cardiac and skeletal muscle development.

Embryonic organoids recapitulate early heart organogenesis

This paper demonstrates that mouse embryonic stem cells can generate heart-like structures with in vivo-like morphogenesis, supporting cardiovascular progenitors and early heart field compartments.

Nkx2-5 defines distinct scaffold and recruitment phases during formation of the cardiac Purkinje fiber network

This study identifies Nkx2-5's role in regulating distinct phases of Purkinje fiber network formation through scaffold establishment and recruitment of conductive precursors.

Hox-dependent coordination of cardiac progenitor cell patterning and differentiation

This study investigates the role of Hoxb1 in regulating cardiac progenitor cell patterning and differentiation, showing its negative regulation of posterior SHF differentiation and its impact on congenital heart defects.

A single cell transcriptional roadmap for cardiopharyngeal fate diversification

This study uses single-cell genomics in Ciona to map cardiopharyngeal fate decisions, revealing FGF-MAPK signaling's role in maintaining multipotency and the Tbx1/10-Dach pathway's role in suppressing the first heart lineage program.

Tbx1 regulates extracellular matrix-cell interactions in the second heart field.

This study shows TBX1 regulates ECM-integrin-focal adhesion signaling in the second heart field, essential for cardiac outflow tract development.

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

This study identifies unique genetic programs for neck muscles and connective tissues in mammals using a 3D model and lineage analysis in mice.