Cell-type-specific ATF6α programs regulate epithelial mitochondrial homeostasis and pericyte remodeling during physiological and exposure-accelerated lung aging
Xuejian Huang, Jonathan Bard, Bat‐Ider Tumenbayar, Kokilavani Vedagiri, Caryn E. Nelson, Harshavardhan Kenche, Celia E. Reynolds, Adriana S. Leme, Stephen J. Moore, Noa A. Perry, Steven D. Shapiro, Yaron Perry, Yongho Bae, Anna Blumental‐Perry
This study shows ATF6α regulates lung aging and remodeling in specific cell types, with distinct effects on epithelial mitochondrial function and pericyte fibrosis.
bioRxiv · Jul 15, 2026 · PreprintCell Biology