Lentiviral CRISPRa/i in the adult Prairie Vole Brain: Modulating Neuronal Gene Expression Without DNA Cleavage
Meredith K. Loth, Kendall T. Mesch, Celine Herrera-Garcia, Liza E. Brusman, Zoe R. Donaldson
This paper develops a lentiviral CRISPRa/i system for non-mutagenic gene regulation in prairie voles, demonstrating bidirectional modulation of social behavior-related genes in specific brain regions.
Frontiers in Genome Editing · May 30, 2025Peer-reviewedMolecular Biology