Zoe R. Donaldson

This study shows that hypothalamic tauP301L pathology in male prairie voles disrupts pair bonding and affects partner preference, suggesting a role for oxytocin signaling in social bonding deficits.

The paper assembles chromosome-scale diploid genomes of prairie and meadow voles using a single-library approach, identifying a prairie-vole-specific duplication of Avpr1a associated with pair bonding.

This study shows that neural synchrony in prairie voles is influenced by bond strength, distance, and interaction time, and is shaped by relationship history.

This study identifies Synaptotagmin-2 and Synaptotagmin-3 as distinct calcium sensors for glutamatergic and GABAergic release in lateral habenula neurons.

The paper maps oxytocin and dopamine receptor expression in prairie and meadow voles to understand their role in pair bonding.

This paper develops a lentiviral CRISPRa/i system for non-mutagenic gene regulation in prairie voles, demonstrating bidirectional modulation of social behavior-related genes in specific brain regions.

The paper examines how exposure to novel females affects testis mass and sperm production in male prairie voles, showing increased reproductive output in socially monogamous males.

This study examines how aging affects pair bonding in prairie voles, finding sex-dependent behavioral changes and increased oxytocin-producing neurons with age.

The paper uses single nucleus RNA-sequencing to show transcriptional synchrony between prairie voles in social relationships, identifying genes in oligodendrocyte progenitor cells linked to dyadic behavior.

This study shows that dopamine release in the nucleus accumbens differs between interactions with pair bonded partners and novel voles, reflecting the selective nature of pair bonds.

PhAT provides a GUI-driven open-source toolkit for photometry analysis, offering signal normalization, event alignment, fluorescence comparison, and modular development.

The paper shows that prolonged partner separation reduces transcriptional signatures of pair bonding in male prairie voles, despite persistent behavioral traits.

The paper identifies a neuronal ensemble in the nucleus accumbens that expands with pair bonding in prairie voles, suggesting it underlies bond formation and maturation.

The paper shows that optogenetic reactivation of socially-active neurons in the infralimbic prefrontal cortex mimics social buffering of fear in mice.

This study investigates the effects of the depression-related SNP rs6295 on 5-HT1A receptor levels and behavior using humanized mouse models.