Gene circuit-driven amplified selection enables evolution of fast-growing Escherichia coli
Grayson S. Hamrick, Hye-In Son, Rohan Maddamsetti, Zhengqing Zhou, Kristen Lok, Xiaoli Chen, Aaron Yip, Jing-Mei Qian, Cesar Villalobos, Qianni Ma, Hossein Moghimianavval, Irida Shyti, Ashwini R. Shende, Emma J. Chory, Mary J. Dunlop, Lingchong You
This paper shows that a synthetic gene circuit can break a growth rate plateau in E. coli by selectively suppressing slow-growing cells, leading to faster growth.
bioRxiv · Aug 6, 2026 · PreprintSynthetic Biology