Grayson S. Hamrick

Gene circuit-driven amplified selection enables evolution of fast-growing Escherichia coli

This paper shows that a synthetic gene circuit can break a growth rate plateau in E. coli by selectively suppressing slow-growing cells, leading to faster growth.

Microscale spatial fragmentation promotes bacterial survival under antibiotics

The paper shows that microscale spatial fragmentation enhances bacterial survival under antibiotics through physical mechanisms, not genetic resistance.

A foundation model for microbial growth dynamics

This paper develops a foundation model for microbial growth dynamics using self-supervised learning on diverse datasets, enabling accurate reconstruction and prediction of growth patterns and antibiotic responses.

Emergence of population-level feedback control by transposon-plasmid coevolution

This study shows how transposon-plasmid coevolution enables Escherichia coli to dynamically respond to antibiotics through population-level feedback control.

Linear scaling reveals low-dimensional structure in observable microbial dynamics

The paper shows that microbial community dynamics can be represented by low-dimensional latent variables, with the critical dimension scaling linearly with observables.

Programming dynamic division of labor using horizontal gene transfer

This paper shows that horizontal gene transfer can enable dynamic division of labor in microbes to stabilize complex metabolic pathways.