Author

Chang-Le Chen

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1

Frequent Co-Authors

Annabelle ColemaniD· 1 shared Cecile D. LadouceuriD· 1 shared Charles M. LaymoniD· 1 shared Dana TudorascuiD· 1 shared Davneet Singh MinhasiD· 1 shared Edward J. WildiD· 1 shared Hecheng JiniD· 1 shared Howard Jay AizensteiniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Annabelle ColemanORCID

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Author profile →

2 papers

Recent·Most cited

Superpixel-ComBat multi-site harmonization of unpaired T1W MRI data in Huntingtons disease

Annabelle Coleman, Chang-Le Chen, Joelle Hanson-Baiden, Davneet Singh Minhas, Mahbaneh Eshaghzadeh Torbati, Charles M. Laymon, Sarah J. Tabrizi, Edward J. Wild, Dana Tudorascu, Rachael I. Scahill, Lauren M. Byrne

This paper adapts Superpixel-ComBat to harmonize unpaired multi-site T1W MRI data in HD, improving image quality and enabling unified VBM analyses across scanners.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Differential Cerebral White Matter Tract Alterations in Generalized Anxiety Disorder Revealed by Ultra-High Field 7T Diffusion-Weighted Imaging

Chang-Le CHEN, Minjie Wu, Yueyang Chi, M E Rose, Jessica C. Weber, Shannon T Lamb, Hecheng Jin, Tamer S. Ibrahim, Cecile D. Ladouceur, Y. Chang, Kuei Yuan Tseng, Howard Jay Aizenstein, Shaolin Yang

This study identifies differential white matter tract alterations in generalized anxiety disorder using 7T diffusion imaging, linking them to symptom severity and diagnostic utility.

Journal of Affective Disorders · May 20, 2026Peer-reviewedNeuroscience