Edward J. Wild

This paper adapts Superpixel-ComBat to harmonize unpaired multi-site T1W MRI data in HD, improving image quality and enabling unified VBM analyses across scanners.

This study estimates the prevalence of HD phenocopy syndromes, finds clinical distinctions are difficult, and uses whole-genome sequencing to identify one ATXN1 expansion in a subcohort.

The paper identifies a deficient PAR response in Huntington disease patients, suggesting a potential therapeutic target for early intervention.

This study identifies Arl8b as a potential biomarker for Alzheimer's disease by analyzing proteomic changes in 5xFAD mouse brain regions and CSF from AD patients.

The paper analyzes CSF endo-lysosomal proteins in HD patients and controls, finding no significant differences in disease state but associations with clinical severity.