Author

Annabelle Coleman

UCL Queen Square Institute of NeurologyORCID 0000-0002-9045-0034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Lauren M. ByrneiD· 2 shared Alexiane TouzéiD· 1 shared Casey R. Herrington· 1 shared Chang-Le Chen· 1 shared Charles M. LaymoniD· 1 shared Chase P. KelleyiD· 1 shared Christopher E. PearsoniD· 1 shared Dana TudorascuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Lauren M. ByrneORCID

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2 papers

Recent·Most cited

Superpixel-ComBat multi-site harmonization of unpaired T1W MRI data in Huntingtons disease

Annabelle Coleman, Chang-Le Chen, Joelle Hanson-Baiden, Davneet Singh Minhas, Mahbaneh Eshaghzadeh Torbati, Charles M. Laymon, Sarah J. Tabrizi, Edward J. Wild, Dana Tudorascu, Rachael I. Scahill, Lauren M. Byrne

This paper adapts Superpixel-ComBat to harmonize unpaired multi-site T1W MRI data in HD, improving image quality and enabling unified VBM analyses across scanners.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.

Terence Gall-Duncan, Sangyoon Y. Ko, Isabelle K. Quick, Mahreen Khan, Kristie Feng, Chase P. Kelley, Annabelle Coleman, Alexiane Touzé, Shuqian Tang, Mustafa Hussain Mehkary, Katsuyuki Yokoi, Casey R. Herrington, Justin You, Scott C. Lambie, Tanya K. Prasolava, , Christopher E. Pearson

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

bioRxiv · Apr 25, 2025 · PreprintGenetics