Author

Changhao Ge

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Hongzhe LiiD· 2 shared Bolin AniD· 1 shared Chao ZhongiD· 1 shared Jing LiniD· 1 shared Lin ZhangiD· 1 shared Peilang Yang· 1 shared Peng HuangiD· 1 shared Qian Zhang· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioinformatics

Hongzhe LiORCID

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Author profile →

3 papers

Recent·Most cited

Robust causal gene network estimation for large-scale single-cell perturbation screens using reduced control function

Changhao Ge, Hongzhe Li

RICE improves causal gene network estimation in single-cell CRISPR screens by addressing confounding, count data, and high-MOI designs, outperforming existing methods in synthetic and real data.

bioRxiv · Jun 16, 2026 · PreprintBioinformatics

RCANE: A Deep Learning Algorithm for Whole-genome Pan-Cancer Somatic Copy Number Aberration Prediction using RNA-seq Data

Changhao Ge, Zhongyi Hu, Lin Zhang, Hongzhe Li

RCANE predicts whole-genome somatic copy number aberrations across cancers using RNA-seq data, outperforming existing methods on TCGA and DepMap datasets.

Communications Biology · Sep 24, 2025Peer-reviewedBioinformatics

Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease

Changhao Ge, Shanshan Jiang, Xiaomin Dong, Xiaoyu Jiang, Weiliang Zhi, Yunqing Xiang, Peilang Yang, Qian Zhang, Xin Chen, Yan Liu, Shuqiang Huang, Yifan Liu, Jing Lin, Bolin An, Peng Huang, Chao Zhong

This paper introduces a living glue made of engineered bacteria that detects and treats inflammatory bowel disease in mice by monitoring bleeding and producing therapeutic proteins.

bioRxiv · Jan 4, 2025 · PreprintSynthetic Biology