Yifan Liu

Deterministic co-encapsulation of microparticles in droplets via synchronized merging for single-cell genomics

The paper develops a method for deterministic co-encapsulation of microparticles in droplets for single-cell genomics, achieving accurate taxonomic profiling of microbial cells.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

Axon Trafficking Counteracts Aberrant Protein Aggregation in Neurons

This study identifies ANXA7 as a critical adaptor for TIA1-containing RNP retrograde transport in axons, showing that its disruption leads to TIA1 aggregation and neurodegeneration.

Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease

This paper introduces a living glue made of engineered bacteria that detects and treats inflammatory bowel disease in mice by monitoring bleeding and producing therapeutic proteins.

Cell extract-based in vitro DNA replication enables sustainable cell-free gene expression

The paper introduces LoopReX, a cell-free gene expression system that enables sustainable DNA replication and protein production through integration of DNA replication machinery.

Large-scale single-cell long-read genomics enables high-resolution microbiome profiling

The paper introduces CAP-seq, a single-cell genomics platform for microbiome analysis, demonstrating strain-level resolution and high genome recovery from microbial communities.

Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

The paper identifies actomyosin-II-driven radial contractility as a mechanism protecting central axons from mild mechanical stress and shows its protective role in a traumatic brain injury model.

Engineering Escherichia coli to utilize erythritol as sole carbon source

This paper engineers Escherichia coli to utilize erythritol as a sole carbon source, enhancing growth and enabling detection of erythritol-containing beverages.

Configurable Compartmentation Enables In vitro Reconstitution of Sustained Synthetic Biology Systems

This paper introduces a strategy for creating configurable hydrogel compartments to enable sustained synthetic biology systems in vitro.

Droplet microfluidic sequencing of HIV genomes and integration sites

This paper introduces a microfluidic method to sequence HIV proviruses and their integration sites, achieving >90% capture and sequencing of paired genomes from treated patients.