Yan Liu

Targeted RNA degradation of HIV-1 TAR element at 5'UTR by CRISPR-Cas13X blocks HIV-1 lytic reactivation

This study uses CRISPR-Cas13X to target HIV-1 TAR RNA, inhibiting viral reactivation and reducing viral load in infected cells.

Scalable methylome-transcriptome profiling resolves clonal organization in human hematopoiesis

This paper introduces Droplet-MT, a method for joint methylome and transcriptome profiling, enabling clonal organization analysis in human hematopoiesis with high scalability and resolution.

DancE: A DNA-Activated Bacterial cGAS-like Enzyme in Antiphage Immune Defense

The paper identifies DancE, a bacterial cGAS-like enzyme activated by DNA, and shows its regulation by DnaK and activation by lambda phage protease gpC.

MCT1 governs a metabolic checkpoint at pachytene during spermatogenesis

This study identifies MCT1 as a metabolic checkpoint regulator in spermatogenesis, showing its role in meiotic progression through epigenetic mechanisms.

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors

This study shows that KSHV and EBV reduce host m5C RNA methylation via c-Myc to destabilize TRIM25 and promote lytic replication.

Zhi-Shi-Huang-Wu slows Parkinson's disease progression in transgenic C. elegans models

The paper evaluates the neuroprotective effects of a traditional Chinese medicine formula, Zhi-Shi-Huang-Wu, in Parkinson's disease models using transgenic C. elegans.

Zhi-Shi-Wu-Huang attenuates amyloid beta toxicity in Caenorhabditis elegans Alzheimer's disease models via modulating insulin DAF-16 signaling pathway

This study evaluates the neuroprotective effects of a traditional Chinese medicine formulation, Zhi-Shi-Wu-Huang, in Caenorhabditis elegans Alzheimer's models by modulating the insulin/DAF-16 signaling pathway.

A Bear-Specific Coding Exon in TMEM41B Is Associated with Cold Adaptation

The paper identifies a bear-specific coding exon in TMEM41B linked to cold adaptation through comparative genomics and functional analysis.

Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population

The paper shows that defects in nephron progenitor cell differentiation lead to an expansion of Foxd1+ stromal progenitors in mouse models and identifies a conserved subcluster in human fetal kidneys.

Determine Protein Interaction Affinity without Purification Reveals a Two-enzyme Co-recognition of SUMOylation Substrate using Quantitative FRET (qFRET) Technology

This paper develops a high-throughput qFRET method to determine protein interaction affinity without purification, revealing a two-enzyme co-recognition mechanism for SUMOylation substrates.

Neural hierarchy for coding articulatory dynamics in speech imagery and production

This paper investigates the neural coding of articulatory dynamics during speech imagery and production, revealing a hierarchical spatiotemporal organization and developing a model to decode speech from neural signals.

Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease

This paper introduces a living glue made of engineered bacteria that detects and treats inflammatory bowel disease in mice by monitoring bleeding and producing therapeutic proteins.

A brain-to-text framework of decoding natural tonal sentences

This paper develops a brain-to-text framework for decoding natural Mandarin tonal sentences from neural recordings, achieving higher accuracy than previous methods.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Transcription and DNA methylation signatures of paternal care in hippocampal dentate gyrus of prairie voles

The paper examines transcription and DNA methylation differences in prairie vole hippocampal dentate gyrus across four behavioral groups, finding gene expression and methylation changes linked to paternal behavior.

Peopling of Tibet Plateau and multiple waves of admixture of Tibetans inferred from both modern and ancient genome-wide data

This paper uses modern and ancient genome-wide data to infer multiple waves of admixture and the peopling of the Tibet Plateau, identifying genetic connections and population stratifications among Tibetans and East Asians.

Hepatic NF-kB-inducing Kinase (NIK) Suppresses Liver Regeneration in Chronic Liver Disease

This study identifies NIK as a suppressor of hepatocyte replication in chronic liver disease, showing that its inactivation promotes liver regeneration.