Lanthanide protein biosensors with a single ion-binding site
Isabella Nymann Westensee, Zhong Guo, Zhenling Cui, Chantal Ronacher, Maria Micaela Fiorito, Alex Beliaev, Kirill A. Alexandrov
This paper develops high-throughput assays for lanthanide-binding proteins using β-lactamase-based biosensors with single ion-binding sites, enabling in vitro and in vivo testing of Ln selectivity and survival.
bioRxiv · Aug 26, 2026 · PreprintSynthetic Biology