Kirill A. Alexandrov

The paper develops a biosensor platform using monomeric streptavidin to evaluate binding domains for small molecules and proteins, demonstrating ligand-dependent activation with biotinylated targets.

This paper develops two high-affinity MTX-binding DNA aptamers using structure-guided methods and validates their use in electrochemical drug monitoring.

This paper develops high-throughput assays for lanthanide-binding proteins using β-lactamase-based biosensors with single ion-binding sites, enabling in vitro and in vivo testing of Ln selectivity and survival.

This study demonstrates the use of a Leishmania cell-free system to express and assay human P450 enzymes 3A4 and 2D6, showing distinct reductase preferences and drug interaction consistency.

The paper investigates tRNA's role in codon selection using split-tRNA, showing that tRNA strain is not essential for GTP hydrolysis and that codon-anticodon stability is influenced by nucleobase dipole moments.

The paper develops genetically encoded fluorescent biosensors for detecting strigolactones using plant receptors, showing specific fluorescence changes in response to strigolactones and their analogs.