Parallel Activation and Interference CRISPR (PAIR) with Sequencing Uncovers DNA Repair Networks Guiding Precision Cell Engineering
Chen Chang, Dailin Gan, Lu Diao, L H Wang, Chantale Lacelle, Gary C. Hon, Jun Li, Min Zhao, Siyuan Zhang
PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.
bioRxiv · May 8, 2026 · PreprintBioengineering