Author

L H Wang

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:gene regulatory network inference· 3 Approach:experimental assay· 2 Research Focus:perturbation response prediction· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Gary C. HoniD· 4 shared Nikhil V Munshi· 2 shared Alessandra CalabreseiD· 1 shared Alessandro MorabitoiD· 1 shared Andrea BelliiD· 1 shared Angela MaurielloiD· 1 shared B Li· 1 shared Beatrice CavalluzzoiD· 1 shared

Activity by Year

2026-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersGenomics

Gary C. HonORCID

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Author profile →

5 papers

Recent·Most cited

Perturb-seq resolves physiologic programs and bidirectional regulation of non-canonical NF-κB signaling in epidermal organoids

Galen T Squiers, Benjamin A. Nanes, Maggie M. Balas, Joshua J. Lingo, L H Wang, Huan Zhao, Sabahat Munawar, Mpathi Nzima, Gary C. Hon, Jason C. Klein

The paper uses Perturb-seq in epidermal organoids to study non-canonical NF-κB signaling's role in keratinocyte differentiation.

bioRxiv · Jul 23, 2026 · PreprintGenomics

Differential serum binding patterns predicting healthy subjects and cancer patients

Beatrice Cavalluzzo, Biancamaria Cembrola, Simona Mangano, Andrea Belli, Francesco Izzo, Rosa D'Angelo, Maria Grazia Chiofalo, Cira Antonietta Forte, Alessandro Morabito, Alessandra Calabrese, Michelino De Laurentiis, Vito Vanella, Paolo A. Ascierto, Fernanda Picozzi, Ottavia Clemente, , Luigi Buonaguro

The paper identifies differential serum binding patterns that classify healthy individuals from cancer patients using serological data from the VirScan platform.

bioRxiv · May 29, 2026 · PreprintImmunology

Combinatorial transcription factor interactions drive modular gene regulatory networks

Jialei Duan, B Li, Kartik Kulkarni, Gabriela Orquera-Tornakian, Daryl Barth, L H Wang, Vrushali Pandit, Joel Liou, Nikhil V Munshi, Gary C. Hon

The paper uses single-cell overexpression screens to study how combinations of transcription factors drive gene regulatory networks and cell-type specific gene expression programs.

bioRxiv · May 21, 2026 · PreprintGenomics

Parallel Activation and Interference CRISPR (PAIR) with Sequencing Uncovers DNA Repair Networks Guiding Precision Cell Engineering

Chen Chang, Dailin Gan, Lu Diao, L H Wang, Chantale Lacelle, Gary C. Hon, Jun Li, Min Zhao, Siyuan Zhang

PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.

bioRxiv · May 8, 2026 · PreprintBioengineering

PEPR-GNN: Perturbation-Enhancer-Promoter-RNA Graph Neural Networks for Multiome Perturb-Seq modeling of regulomes

Zachary Markham, Boxun Li, Landon Vu Nguyen, L H Wang, Nikhil V Munshi, Gary C. Hon

The paper introduces PEPR-GNN, a graph neural network framework to model regulome responses during genetic perturbations using Multiome Perturb-Seq data.

bioRxiv · May 6, 2026 · PreprintGenomics