MRN-ATM Pathway Activation in CD4 T-Cell Senescence during Chronic Hepatitis B Virus Infection
Xiaoying Deng, Xiaoyan Wang, Yi Li, Fangfang Li, Jun Xiong, Hongyan Shi, Yun Zhou, Chuantao Ye, X H Zheng, Jianqi Lian, Chao Fan, Ying Zhang
This study shows that chronic HBV infection causes CD4 T-cell senescence with DNA damage and telomere erosion, while the MRN-ATM pathway is activated as a compensatory mechanism to maintain T-cell function.
bioRxiv · Mar 18, 2026 · PreprintImmunology