ImmunologybioRxivPreprint
MRN-ATM Pathway Activation in CD4 T-Cell Senescence during Chronic Hepatitis B Virus Infection
Xiaoying Deng, Xiaoyan Wang, Yi Li…·Ying Zhang
This study shows that chronic HBV infection causes CD4 T-cell senescence with DNA damage and telomere erosion, while the MRN-ATM pathway is activated as a compensatory mechanism to maintain T-cell function.
DOI 10.64898/2026.03.15.711849