HER3 mediates metabolic reprogramming in metastatic colorectal and pancreatic cancer
Moeez Rathore, Chao Wei, Jordan Winter, Rui Wang
This study shows HER3 drives glycolysis in liver metastases of CRC and PDAC, and HER3 inhibition increases OXPHOS dependency, which can be targeted with combined therapy.
bioRxiv · Nov 3, 2026 · PreprintCancer Biology