Intergenerational Stress Transmission is Associated with Brain Metabotranscriptome Remodeling andMitochondrial Dysfunction
Sammy Alhassen, Siwei Chen, Lamees Alhassen, Alvin Phan, Mohammad Khoudari, Angele De Silva, Huda Barhoosh, Zitong Wang, Chelsea Marie T. Parrocha, Emily Shapiro, Charity Henrich, Zicheng Wang, Léon Mutesa, Pierre Baldi, Geoffrey Winston Abbott, Amal Alachkar
This study shows that prenatal stress exposure in mice leads to behavioral deficits in offspring, associated with mitochondrial dysfunction and epigenetic changes, which can be mitigated by acetyl-L-carnitine.
Communications Biology · Jun 24, 2021Peer-reviewedNeuroscience