Siwei Chen

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

The paper investigates cellular mechanisms of brain overgrowth in autistic children with megalencephaly, finding elevated GPX4 and resistance to ferroptosis in neural progenitor cells.

The paper infers sex-specific meiotic recombination landscapes from low-coverage embryo sequencing data, revealing chromosome-specific patterns linked to aneuploidies.

Rare-variant depletion in 1kb windows of 76,156 gnomAD genomes, versus feature-adjusted mutation expectations, marks regulatory elements and outperforms seven alternative scores at flagging functional non-coding variants.

The paper investigates how fasting-induced beta-hydroxybutyrate (BHB) affects histone modifications and gene expression in mouse brain tissue, revealing its role in modulating circadian rhythms and epigenetic landscapes.

This study shows that prenatal stress exposure in mice leads to behavioral deficits in offspring, associated with mitochondrial dysfunction and epigenetic changes, which can be mitigated by acetyl-L-carnitine.

This paper introduces a new global feature score (GFS) to identify brain regions related to Alzheimer's disease using network analysis, showing it outperforms local features and correlates with cognitive assessments.

The paper shows that inhibiting HDAC1 and HDAC2 improves CRISPR/Cas9 gene editing efficiency by opening chromatin and enhancing Cas9 access.