Pierre Baldi

The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function

This study shows the liver clock regulates transcriptional rhythms in skeletal muscle, affecting mitochondrial function through endocrine communication.

Succinate Modulation as a Novel Mechanism Underlying the Effects of Intermittent Fasting on Brain Function and Metabolism in Diet-Induced Obesity

Performance of Large Language Models on Pharmacy Exam: A Comparative Assessment Using the NAPLEX

This study evaluates six LLMs on a pharmacy exam, finding GPT-4 performs best with 87.1% accuracy, suggesting potential impacts on pharmacy education and practice.

Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation

This study maps cilia length and orientation across mouse brain regions over 24 hours, revealing region-specific circadian rhythms and non-random orientation patterns.

Brain histone beta-hydroxy-butyrylation couples metabolism with gene expression

The paper investigates how fasting-induced beta-hydroxybutyrate (BHB) affects histone modifications and gene expression in mouse brain tissue, revealing its role in modulating circadian rhythms and epigenetic landscapes.

Intergenerational Stress Transmission is Associated with Brain Metabotranscriptome Remodeling andMitochondrial Dysfunction

This study shows that prenatal stress exposure in mice leads to behavioral deficits in offspring, associated with mitochondrial dysfunction and epigenetic changes, which can be mitigated by acetyl-L-carnitine.

The circadian hippocampus and its reprogramming in epilepsy: impact for chronotherapeutics

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

Fold recognition by scoring protein map similarities using the congruence coefficient

The paper introduces the congruence coefficient as a similarity metric for protein map comparison, showing it improves fold recognition over existing methods.

Protein Profiles: Biases and Protocols

The paper evaluates the role of evolutionary profiles in protein secondary structure prediction and introduces a new protocol to fairly compare profile-based predictors.

Hippocampal ensembles represent sequential relationships among discrete nonspatial events

This study identifies sequential organization in hippocampal activity during nonspatial event sequences, revealing time cells and compressed temporal representations.

Preoperative predictions of in-hospital mortality using electronic medical record data

This paper develops a machine learning model using EMR data to predict in-hospital mortality preoperatively, achieving higher accuracy than existing clinical scores.

Functional conservation of lncRNA JPX despite sequence and structural divergence

The paper investigates the functional conservation of lncRNA JPX across species despite sequence and structural divergence, showing it can functionally complement Jpx in mouse cells.

The accumulation of N6-methyl-2-deoxyadenosine in DNA drives activity-induced gene expression and is required for the extinction of conditioned fear

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.

Epigenetic regulation of the circadian gene Per1 in the hippocampus mediates age-related changes in memory and synaptic plasticity

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.

Genome Architecture Leads a Bifurcation in Cell Identity

This study shows that MYOD1-mediated reprogramming of human fibroblasts into muscle cells involves a genome architecture bifurcation point preceding transcriptional changes.