Restricted MHC-II trafficking in Mycobacterium tuberculosis-infected M2-like macrophages limits CD4+ T cell activation
Avinaash K. Sandhu, Daniel P. Gail, Rachel C. Simmermon, Demetria Webb, Laura Hmiel, Charles Bark, Bryan D. Bryson, Richard F. Silver, Stephen M. Carpenter
This study identifies IL-10 and type I IFN signaling as mechanisms that restrict MHC-II trafficking in Mtb-infected M2-like macrophages, limiting CD4+ T cell activation.
bioRxiv · Jul 10, 2026 · PreprintImmunology