Author

Daniel P. Gail

Case Western Reserve UniversityORCID 0000-0002-9792-1556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Stephen M. CarpenteriD· 3 shared Avinaash K. SandhuiD· 2 shared Bryan D. BrysoniD· 2 shared Scott M. RebaiD· 2 shared Vinicius G. SuzartiD· 2 shared Alessandro SetteiD· 1 shared Bianca A. Lepe· 1 shared Cecilia S. Lindestam ArlehamniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Stephen M. CarpenterORCID

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3 papers

Recent·Most cited

Human memory CD4+ T cells recognize non-infected macrophage bystanders exposed to Mycobacterium tuberculosis-infected cells

Vinicius G. Suzart, Robert Schauner, Scott M. Reba, Daniel P. Gail, Gwendolyn M. Swarbrick, David Michael Lewinsohn, Deborah A. Lewinsohn, Bianca A. Lepe, Bryan D. Bryson, Samuel M. Behar, Christopher M. Sassetti, Michael L. Freeman, W Henry Boom, Clifford V. Harding, Stephen M. Carpenter

The paper shows human memory CD4+ T cells recognize both Mtb-infected and bystander macrophages, with some TCRs specifically recognizing infected cells.

bioRxiv · Sep 24, 2026 · PreprintImmunology

Restricted MHC-II trafficking in Mycobacterium tuberculosis-infected M2-like macrophages limits CD4+ T cell activation

Avinaash K. Sandhu, Daniel P. Gail, Rachel C. Simmermon, Demetria Webb, Laura Hmiel, Charles Bark, Bryan D. Bryson, Richard F. Silver, Stephen M. Carpenter

This study identifies IL-10 and type I IFN signaling as mechanisms that restrict MHC-II trafficking in Mtb-infected M2-like macrophages, limiting CD4+ T cell activation.

bioRxiv · Jul 10, 2026 · PreprintImmunology

Human memory CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses

Volodymyr Stetsenko, Daniel P. Gail, Scott M. Reba, Vinicius G. Suzart, Avinaash K. Sandhu, Alessandro Sette, Mohammad Haj Dezfulian, Cecilia S. Lindestam Arlehamn, Stephen M. Carpenter

The paper shows that most Mtb-specific CD4+ T cells from LTBI individuals recognize infected macrophages, but some require exogenous antigen, and identifies effector functions associated with TB protection.

bioRxiv · Feb 23, 2025 · PreprintImmunology