Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis
Nicole L. Eliason, Kevin Pham, Rohan Varshney, Jacob W. Farriester, Charles I. Lacy, Heather C. Rice, Michael C. Rudolph, Willard M. Freeman, Amanda Lea Sharpe
This study shows that deleting melanocortin-4 receptors on hypothalamic astrocytes increases body weight, feeding, and central inflammation, independent of neuronal MC4R effects.
bioRxiv · Dec 1, 2022 · PreprintNeuroscience