Rohan Varshney

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

Large adipocytes alter mode of lipid release and promote breast cancer malignancy

This study shows that large adipocytes release lipids via extracellular vesicles, promoting breast cancer cell migration and proliferation, and links this to human dyslipidemia and triglyceride levels.

Disulfiram Protects Against Diet-Induced Obesity by Reprogramming Systemic Lipid Partitioning Independent of GSDMD

This study shows Disulfiram protects against obesity and insulin resistance through GSDMD-independent mechanisms by reprogramming systemic lipid handling.

Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

This study shows that the Wnt/lipogenesis axis mediates lipodystrophy and recovery in skin fibrosis by regulating lipid content and extracellular matrix.

Maternal exercise during lactation reprograms obesity-related changes in mammary metabolism to optimize milk fatty acids and offspring energy expenditure

This study shows that maternal exercise during lactation improves milk fatty acid composition and enhances offspring energy expenditure in obese dams.

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis

This study shows that deleting melanocortin-4 receptors on hypothalamic astrocytes increases body weight, feeding, and central inflammation, independent of neuronal MC4R effects.