Heather C. Rice

Female microglia show heightened responses to aging and amyloid pathology in mice and humans

The paper identifies conserved sex-biased microglial responses to aging and amyloid pathology in mice and humans using single-cell transcriptomics and proteomics.

Amyloid precursor protein interacts with the mitochondrial phosphatase PGAM5 and regulates mitochondrial respiration

This study identifies an interaction between APP and PGAM5, showing that APP regulates mitochondrial respiration by modulating Keap1-Nrf2 signaling.

sAPPalpha inhibits neurite outgrowth in primary mouse neurons via GABA B Receptor subunit 1a

The paper shows sAPPalpha inhibits neurite outgrowth in mouse neurons via GABABR1a, with sAPP requiring the extension domain to bind GABABR1a and suppress axon growth.

Oligodendrocytes show enriched expression of amyloid precursor protein and GABA B receptor isoform 1a

The paper shows GABABR1a is most expressed in oligodendrocytes and APP is most expressed in oligodendrocytes among five brain cell types.

Modeling presynaptic inhibition by the amyloid precursor protein demonstrates one potential mechanism for preventing runaway synaptic modification in Alzheimers disease

The paper models presynaptic inhibition by sAPP-GABABR1a to show how it prevents runaway synaptic modification in Alzheimer's disease.

Protocol to isolate oligodendrocytes, microglia, endothelial cells, astrocytes, and neurons from a single mouse brain using magnetic-activated cell sorting

This paper describes a protocol for isolating five specific brain cell types from a single mouse brain using magnetic-activated cell sorting.

Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing

The paper investigates the role of tau in VTA dopamine neuron dysfunction in Alzheimer's disease models, finding that tau induces hyperexcitability but impairs burst firing.

Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans

The paper identifies microglia as the primary source of MHC-I in mice and humans, showing age-related and Alzheimer's-associated increases in MHC-I expression and related receptors.

Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis

This study shows that deleting melanocortin-4 receptors on hypothalamic astrocytes increases body weight, feeding, and central inflammation, independent of neuronal MC4R effects.