Antagonistic Regulation of LINE-1/Alu Elements and Their Repressor APOBEC3B in Cellular Senescence
Daksha Munot, Yueshuang Lu, Isabell Haußmann, Gregoire Najjar, Charlotte Baur, Manvendra Kumar Singh, Çagatay Güneş, Daniel Sauter, Ankit Ved Arora
This study identifies APOBEC3B depletion as a driver of L1 element derepression and increased DNA damage in senescent cells through high-throughput sequencing and Ribo-seq analysis.
Mobile DNA · Oct 21, 2025Peer-reviewedGenomics