Author

Matthew Wyles

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Matthew D. ParkeriD· 2 shared Abha ChopraiD· 1 shared Adam CaulderiD· 1 shared Adrian Higginbottom· 1 shared Adrian M. IsaacsiD· 1 shared Adrienn AngyaliD· 1 shared Alain KohliD· 1 shared Alexander J Keeley· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Matthew D. ParkerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Astrocyte dysfunction distinguishes monozygotic twin C9orf72 expansion carriers discordant for amyotrophic lateral sclerosis.

Allan Christian Shaw, Iris-Stefania Pasniceanu, Rebecca Stevenson, Chloé Moutin, Gergo Erdi-Krausz, Matthew D. Parker, Matthew Wyles, Cleide Dos Santos Souza, Adrian Higginbottom, Lydia M. Castelli, Janine Kirby, Guillaume M. Hautbergue, Laura Ferraiuolo, Johnathan Cooper‐Knock, Matthew R. Livesey, Pamela J. Shaw

This study identifies distinct astrocyte states in C9orf72 expansion carriers discordant for ALS, linking epigenetic changes, stress, and functional dysfunction to disease onset.

bioRxiv · Jul 20, 2026 · PreprintNeuroscience

Generation of C9orf72h370 mice, an intron 1 humanised C9orf72 repeat-expansion knock-in model

R. Nair, Mireia Carcolé, David Thompson, Charlotte Tibbit, Ross McLeod, Alexander J. Cammack, Tatiana Jakubcova, Daniel Biggs, Matthew Wyles, Matthew T Parker, Adam Caulder, Lydia Teboul, Chloe L Fisher-Ward, Ali R Awan, Michael D. Flower, , Thomas J. Cunningham

The paper generates a mouse model with a humanised C9orf72 repeat expansion to study ALS and FTD, and demonstrates a method for creating such repeat expansions in genomic sequences.

bioRxiv · Feb 6, 2025 · PreprintMolecular Biology

periscope: Sub-Genomic RNA Identification in SARS-CoV-2 Genomic Sequencing Data

Matthew D. Parker, Benjamin B. Lindsey, Shay Leary, Silvana Gaudieri, Abha Chopra, Matthew Wyles, Adrienn Angyal, Luke R. Green, Paul Parsons, Rachel M Tucker, Rebecca Brown, Danielle Groves, Katie Johnson, Laura Carrilero, Joe Heffer, , Thushan I. de Silva

Periscope identifies and quantifies sub-genomic RNAs in SARS-CoV-2 genomic data, detecting canonical and non-canonical sgRNAs with high fidelity.

Genome Research · Apr 1, 2021Peer-reviewedBioinformatics