Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Julio C.Y. Liu, Leena Ackermann, Saskia Hoffmann, Zita Gál, Ivo Alexander Hendriks, Charu Jain, Louise Morlot, Michael H. Tatham, Gian‐Luca McLelland, Ronald T. Hay, Michael Lund Nielsen, Thijn R. Brummelkamp, Peter Haahr, Niels Mailand
The paper identifies TOPORS as a SUMO-targeted ubiquitin ligase (STUbL) essential for SUMO-dependent DNA-protein crosslink repair and stress responses, showing its cooperative function with RNF4.
Nature Structural & Molecular Biology · Apr 22, 2024Peer-reviewedMolecular Biology