Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Julio C.Y. Liu, Leena Ackermann, Saskia Hoffmann…·Niels Mailand
The paper identifies TOPORS as a SUMO-targeted ubiquitin ligase (STUbL) essential for SUMO-dependent DNA-protein crosslink repair and stress responses, showing its cooperative function with RNF4.
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