Author
University of DundeeORCID 0000-0001-6986-1691Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Sarah Chandler, Michael H. Tatham, Emma Branigan…·Ronald T. Hay
The paper develops a photocrosslinking activity-based probe to study interactions between ubiquitin and RING E3 ligases, confirming existing structures and evaluating new models.
Martin Grønbæk-Thygesen, Caroline Kampmeyer, Paula Eschger…·Rasmus Hartmann‐Petersen
This study shows that ubiquitylation of UBQLN2's UBL domain regulates its stability and localization, with implications for proteasomal degradation and ALS.
Julio C.Y. Liu, Leena Ackermann, Saskia Hoffmann…·Niels Mailand
The paper identifies TOPORS as a SUMO-targeted ubiquitin ligase (STUbL) essential for SUMO-dependent DNA-protein crosslink repair and stress responses, showing its cooperative function with RNF4.
Charlotte Crowe, Mark A. Nakasone, Sarah Chandler…·Alessio Ciulli
The paper solves cryo-EM structures of a degrader-mediated complex to reveal structural insights into target protein ubiquitination mechanisms.