Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Qing Dai, Tanner Baldwin, Ruitu Lyu, Bryan Daniels, Chang Ye, Chen Cao, Chenyou Zhu, Diwen Fan, Liane Lin, Yushuai Liu, Yiding Wang, Chuan He
UMBS-seq improves 5-methylcytosine detection in low-input DNA by reducing degradation and noise, outperforming existing methods in yield and efficiency.
Nature Communications · Nov 13, 2025Peer-reviewedGenomics