Yiding Wang

This paper introduces BALT-seq, a one-step chemoselective method for hydroxymethylcytosine profiling in DNA and RNA, showing high concordance with existing methods and improved RNA enrichment.

UMBS-seq improves 5-methylcytosine detection in low-input DNA by reducing degradation and noise, outperforming existing methods in yield and efficiency.

This study shows that Pseudomonas aeruginosa inactivates its type I R-M system via proteolysis at high temperatures, leading to prolonged genomic hypomethylation and a memory effect lasting over 60 generations.