Author

Chenyou Zhu

Howard Hughes Medical InstituteORCID 0000-0003-2682-9565Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Organism:mouse· 1

Frequent Co-Authors

Chuan HeiD· 2 shared Qing DaiiD· 2 shared Ruitu LyuiD· 2 shared Yiding WangiD· 2 shared Arvin Yanchu Wang· 1 shared Bryan Daniels· 1 shared Chang YeiD· 1 shared Chen Cao· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Chuan HeORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 17, 2026

A One-Step Chemoselective Strategy for Hydroxymethylcytosine Sequencing in DNA and RNA

Jiahao Li, Peihong Zhang, Arvin Yanchu Wang…·Chuan He

This paper introduces BALT-seq, a one-step chemoselective method for hydroxymethylcytosine profiling in DNA and RNA, showing high concordance with existing methods and improved RNA enrichment.

DOI 10.64898/2026.09.14.751533

mouseDNA methylation

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GenomicsNature CommunicationsPeer-reviewedNov 13, 2025

Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA

Qing Dai, Tanner Baldwin, Ruitu Lyu…·Chuan He

UMBS-seq improves 5-methylcytosine detection in low-input DNA by reducing degradation and noise, outperforming existing methods in yield and efficiency.

10 citations

DNA methylationexperimental assay

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