Author

Yushuai Liu

Van Andel InstituteORCID 0000-0002-2011-1926Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:Hi-C· 1

Frequent Co-Authors

Haley GoreiD· 3 shared Pamela HimadewiiD· 3 shared Xiaotian ZhangiD· 3 shared Xue Qing David WangiD· 3 shared Fan FengiD· 2 shared Wanding ZhouiD· 2 shared Xinyu WangiD· 2 shared Aviva Presser AideniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersGenomics

Haley GoreORCID

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Author profile →

4 papers

Recent·Most cited

Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA

Qing Dai, Tanner Baldwin, Ruitu Lyu, Bryan Daniels, Chang Ye, Chen Cao, Chenyou Zhu, Diwen Fan, Liane Lin, Yushuai Liu, Yiding Wang, Chuan He

UMBS-seq improves 5-methylcytosine detection in low-input DNA by reducing degradation and noise, outperforming existing methods in yield and efficiency.

Nature Communications · Nov 13, 2025Peer-reviewedGenomics

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

Pamela Himadewi, Xue Qing David Wang, Fan Feng, Haley Gore, Yushuai Liu, Lei Yu, Jie Liu, Ryo Kurita, Yukio Nakamura, Gerd Pfeifer, Xiaotian Zhang

The paper shows that deleting the 3HS1 CTCF binding site increases fetal hemoglobin expression in hematopoietic stem cells and erythroid progenitor cells, suggesting therapeutic potential for hemoglobinopathies.

eLife · Sep 29, 2021Peer-reviewedGenomics

A Cell Type-Specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

Xiaotian Zhang, Mira Jeong, Xingfan Huang, Xue Qing David Wang, Xinyu Wang, Wanding Zhou, Muhammad S. Shamim, Haley Gore, Pamela Himadewi, Yushuai Liu, Ivan D. Bochkov, Jaime M. Reyes, Madison Doty, Yung‐Hsin Huang, Haiyoung Jung, , Margaret A. Goodell

The paper identifies cell type-specific chromatin loops anchored at large DNA methylation nadirs, revealing their role in stem and progenitor cell function.

Molecular Cell · May 1, 2020Peer-reviewedGenomics

Three-dimensional regulation of HOXA cluster genes by a cis-element in hematopoietic stem cell and leukemia.

Xue Qing David Wang, Haley Gore, Pamela Himadewi, Fan Feng, Lu Yang, Wanding Zhou, Yushuai Liu, Xinyu Wang, Chun-Wei David Chen, Jianzhong Su, Jie Liu, Gerd P. Pfeifer, Xiaotian Zhang

The paper investigates how 3D chromatin interactions regulate HOXA cluster genes in HSCs and leukemia by analyzing the role of the Geneless Canyon region.

bioRxiv · Apr 16, 2020 · PreprintGenomics