Amyloid-beta, p-tau, and reactive microglia load are correlates of MRI cortical atrophy in Alzheimer's disease
Irene Frigerio, Baayla D.C. Boon, Chen-Pei Lin, Yvon Galis-de Graaf, John G. J. M. Bol, Paolo Preziosa, Jos W. R. Twisk, Frederik Barkhof, Jeroen J.M. Hoozemans, Femke H Bouwman, Annemieke J.M. Rozemüller, Wilma D. J. van de Berg, Laura E. Jonkman
This study identifies histopathological correlates of MRI cortical atrophy in Alzheimer's disease, finding that phosphorylated-tau and reactive microglia loads strongly correlate with atrophy in specific brain regions.
bioRxiv · Jun 16, 2021 · PreprintNeuroscience