Jeroen J.M. Hoozemans

Genetic Variants that Modulate Alzheimer's Disease Risk Deregulate Protein-Protein Correlations in the Gyrus Temporalis Medius

The paper identifies genetic variants associated with protein abundance and altered protein-protein correlations in the Gyrus Temporalis Medius in Alzheimer's Disease patients.

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathology

This study uses single-nucleus and spatial transcriptomics to identify cell type-specific associations with Alzheimer's disease pathology in human temporal cortex and white matter.

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer's disease

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

Amyloid-beta, p-tau, and reactive microglia load are correlates of MRI cortical atrophy in Alzheimer's disease

This study identifies histopathological correlates of MRI cortical atrophy in Alzheimer's disease, finding that phosphorylated-tau and reactive microglia loads strongly correlate with atrophy in specific brain regions.

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

Neuropathology and cognitive performance in centenarians

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

The paper identifies two VH5-51/VL4-1 antibodies that recognize a common tau antigenic motif and have distinct functionalities in blocking tau aggregation and mediating microglial uptake.