Wilma D. J. van de Berg

This paper uses cryo-ET to study amyloid fibrils in neurodegenerative brain tissue, revealing ultrastructural details of fibril polymorphs and their association with disease.

This study uses correlative light and electron microscopy to characterize the ultrastructural changes in tau fibrils during ghost tangle formation in Alzheimer's disease brain tissue.

This study uses correlative light and electron microscopy to analyze Lewy body pathology in Parkinson's and dementia with Lewy bodies, revealing regional differences in ultrastructure and mitochondrial changes.

The paper examines ultrastructural differences between somatic and neuritic Lewy body inclusions in Parkinson's disease using correlative light and electron microscopy.

The paper analyzes myelin structure and protein abundance in skin biopsies from synucleinopathy patients to identify structural differences and potential biomarkers.

This paper provides a protocol for correlative light and electron microscopy (CLEM) optimized for analyzing human brain tissue, enabling detailed ultrastructural analysis and characterization of subcellular features.

This study induces alpha-Synuclein aggregation in the gigantocellular nuclei of transgenic mice to model prodromal Parkinson's disease and observe motor symptom progression.

The paper identifies region-specific laminar gene expression patterns in language-related cortical areas and links them to structural connectivity and dyslexia risk.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

The paper quantifies regional synaptic degeneration in Parkinson's Disease and Dementia with Lewy bodies, linking it to alpha-synuclein burden, axonal damage, and clinical outcomes.

The paper examines TFEB subcellular localization in Parkinson's and Lewy body disease brains, finding altered distribution linked to disease stages and GBA variants.

This study uses diffusion MRI and histopathology to show that microstructural changes in the substantia nigra and its tracts in Parkinson's disease correlate with dopaminergic loss and Lewy neurite pathology.

This study examines the regional distribution of neurofilaments in Parkinson's disease and its association with pathological markers and MRI measures of brain atrophy and diffusivity.

The paper examines how structural connectivity changes relate to cholinergic cell density in the nucleus basalis of Meynert in Alzheimer's disease, finding specific associations in amnestic cases.

This study identifies histopathological correlates of MRI cortical atrophy in Alzheimer's disease, finding that phosphorylated-tau and reactive microglia loads strongly correlate with atrophy in specific brain regions.

The paper identifies transcriptomic signatures of brain regional vulnerability to Parkinson’s disease by analyzing gene expression patterns across Braak Lewy body stages in human brain datasets.

The paper identifies gene expression changes in brain regions with gray matter loss in Parkinson's disease and links them to cholinergic circuits and signaling pathways.

The paper identifies ChAT-VIP interneurons in the medial prefrontal cortex that use cholinergic transmission to excite neurons and influence attention.

The paper uses 3D multicolor STED microscopy to study subcellular distribution of alpha-synuclein variants in Parkinson’s disease brains, revealing their association with pathology.

The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.

This study examines the distribution of α-synuclein pathology in insular cortex sub-regions in Parkinson’s disease and dementia with Lewy bodies, revealing regional differences in vulnerability.