Author

Chen-Yang Lai

The University of Queensland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ashar J. MalikiD· 1 shared Aude G. BernheimiD· 1 shared Boštjan KobeiD· 1 shared Chacko JobicheniD· 1 shared David Benjamin AscheriD· 1 shared Gavin J. KnottiD· 1 shared Jeremy J. BarriD· 1 shared Jovita D'Silva· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ashar J. MalikORCID

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1 paper

Recent·Most cited

Structural basis of coiled-coil domain-mediated inhibition of A. baumannii AbTir NAD+ nucleosidase activity

Weixi Gu, Mohammad Kawsar Manik, Chacko Jobichen, Matthieu Haudiquet, Jovita D'Silva, Chen-Yang Lai, Sulin Li, Xiaoqi Qian, Ashar J. Malik, David Benjamin Ascher, Randy J. Read, Jeremy J. Barr, Wai‐Hong Tham, Aude G. Bernheim, Gavin J. Knott, Boštjan Kobe

This study determines the crystal structure of AbTir, revealing how its coiled-coil domain inhibits NAD+ nucleosidase activity by disrupting symmetry and preventing NAD+ binding site formation.

bioRxiv · Oct 7, 2026 · PreprintBiochemistry