Wai‐Hong Tham

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

This study determines the crystal structure of AbTir, revealing how its coiled-coil domain inhibits NAD+ nucleosidase activity by disrupting symmetry and preventing NAD+ binding site formation.

This study identifies nanobodies that target Plasmodium adhesins, blocking receptor engagement and inhibiting parasite invasion of red blood cells.

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

The paper shows iron deficiency reduces Plasmodium parasitemia in pregnant women and mice, and iron supplementation does not increase parasitemia when combined with malaria prevention.

alpseq is an open-source pipeline for processing NGS data from nanobody libraries, enabling efficient analysis and identification of enriched sequences.

This paper identifies nanobodies against Pfs48/45 that reduce malaria parasite transmission by inhibiting fertilization in Anopheles mosquitoes.

The paper identifies nanobodies targeting domain 3 of PfHAP2 and determines its crystal structure, providing structural insights for transmission-blocking interventions against malaria.

The paper presents analyses to assess selection dynamics in multi-round protein selection experiments, offering insights into diversity, coverage, and reproducibility.

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

This study evaluates how genetic diversity in Plasmodium vivax antigens affects serological markers for malaria exposure and finds that using multiple antigens can improve detection accuracy.

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

The paper isolates a human monoclonal antibody that targets Plasmodium vivax AMA1, blocking both pre-erythrocytic and blood stage infections.